INTRACELLULAR ORGANIC PHOSPHATES AS REGULATORS OF OXYGEN RELEASE BY HAEMOGLOBIN

被引：495

作者：

BENESCH, R

BENESCH, RE

机构：

[1] Department of Biochemistry, Columbia University, College of Physicians and Surgeons

来源：

NATURE | 1969年 / 221卷 / 5181期

关键词：

D O I：

10.1038/221618a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

2,3-Diphosphoglycerate is present in the red cells of many species at about equimolar concentration to haemoglobin. It lowers the oxygen affinity and thus facilitates oxygen unloading because it is preferentially bound to deoxyhaemoglobin in the ratio of one mole per tetramer. © 1969 Nature Publishing Group.

引用

收藏

页码：618 / &

相关论文

共 60 条

[1] The identity of h ae moglobin in human beings. [J].

Adair, GS ;

Barcroft, J ;

Bock, AV .

JOURNAL OF PHYSIOLOGY-LONDON, 1921, 55 (5/6) :332-338

[2] RESTORATION OF DEFECTIVE OXYGEN-TRANSPORT FUNCTION OF STORED RED BLOOD CELLS BY ADDITION OF INOSINE [J].

AKERBLOM, O ;

DEVERDIE.CH ;

GARBY, L ;

HOGMAN, C .

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1968, 21 (03) :245-&

[3]

ASAKURA T, 1966, J BIOCHEM-TOKYO, V5, P524

[4] INFLUENCE OF TEMPERATURE AND PH ON DISSOCIATION CURVE OF OXYHEMOGLOBIN OF HUMAN BLOOD [J].

ASTRUP, P ;

ENGEL, K ;

SEVERING.JW ;

MUNSON, E .

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1965, 17 (06) :515-&

[5]

ASTRUP P, 1968, SCAND J CLIN LAB INV, V22, P171

[6] PHOSPHORYLATED CARBOHYDRATE INTERMEDIATES OF HUMAN ERYTHROCYTE DURING STORAGE IN ACID CITRATE DEXTROSE .2. EFFECT OF ADDITION OF INOSINE LATE IN STORAGE [J].

BARTLETT, GR ;

SHAFER, AW .

JOURNAL OF CLINICAL INVESTIGATION, 1961, 40 (07) :1185-&

[7] CHANGES IN THE PHOSPHATE COMPOUNDS OF THE HUMAN RED BLOOD CELL DURING BLOOD BANK STORAGE [J].

BARTLETT, GR ;

BARNET, HN .

JOURNAL OF CLINICAL INVESTIGATION, 1960, 39 (01) :56-61

[8] PHOSPHATE COMPOUNDS OF THE RABBIT RED BLOOD CELL DURING STORAGE IN ACID CITRATE DEXTROSE (ACD) AND ACD-INOSINE [J].

BARTLETT, GR ;

SHAFER, AW .

JOURNAL OF CLINICAL INVESTIGATION, 1960, 39 (01) :62-68

[9] CARBOHYDRATE INTERMEDIATES AND RELATED COFACTORS IN THE HUMAN ERYTHROCYTE [J].

BARTLETT, GR ;

SAVAGE, E ;

HUGHES, L ;

MARLOW, AA .

JOURNAL OF APPLIED PHYSIOLOGY, 1953, 6 (01) :51-56

[10] EFFECT OF ORGANIC PHOSPHATES FROM HUMAN ERYTHROCYTE ON ALLOSTERIC PROPERTIES OF HEMOGLOBIN [J].

BENESCH, R ;

BENESCH, RE .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1967, 26 (02) :162-&

← 1 2 3 4 5 6 →