NEW ROLES FOR G-PROTEIN BETA-GAMMA-DIMERS IN TRANSMEMBRANE SIGNALING

被引：613

作者：

CLAPHAM, DE

NEER, EJ

机构：

[1] HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA

[2] BRIGHAM & WOMENS HOSP, DEPT MED, BOSTON, MA 02115 USA

来源：

NATURE | 1993年 / 365卷 / 6445期

关键词：

D O I：

10.1038/365403a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

When a membrane-bound receptor acts on a G protein, the GTP-binding or G(alpha) subunit dissociates from the G(betagamma) dimer. Until recently, the G(alpha) subunit alone was thought to act on the enzymes and ion channels controlled by these proteins. Newer evidence indicates that the G(betagamma) dimer also plays a major part in signal transmission, enhancing the complexity of the possible interactions between the G proteins and their targets.

引用

页码：403 / 406

页数：4

共 71 条

[1] REGULATION OF DEACTIVATION OF PHOTORECEPTOR G-PROTEIN BY ITS TARGET ENZYME AND CGMP [J].