FIELD TRIAL OF A VACCINE AGAINST AMERICAN DERMAL LEISHMANIASIS

被引：106

作者：

MAYRINK, W ^{[1
]}

DACOSTA, CA ^{[1
]}

MAGALHAES, PA ^{[1
]}

MELO, MN ^{[1
]}

DIAS, M ^{[1
]}

OLIVEIRALIMA, A ^{[1
]}

MICHALICK, MS ^{[1
]}

WILLIAMS, P ^{[1
]}

机构：

[1] SUPERINTENDENCIA CAMPANHAS,MINIST SAUDE,SETOR CARATINGA,MG,BRAZIL

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1979年 / 73卷 / 04期

关键词：

D O I：

10.1016/0035-9203(79)90159-7

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A field trial was carried out in the eastern part of the State of Minas Gerais (Brazil) of a vaccine containing killed promastigoies of five stocks of Leishmania. Tests with Montenegro antigen showed that a high proportion of the vaccinated persons became positive within three months, but circulating antibodies were not detected. A proportion of those vaccinated continued to give positive Montenegro reactions for up to three years. Lymphocyte sensitivity tests carried out, on a small sample, three years after vaccination were positive and gave no evidence of immunological depression. No cases of cutaneous or mucocutaneous leishmaniasis occurred in the trial area during the three years of observations. © 1979 Oxford University Press.

引用

页码：385 / 387

页数：3