A ROLE FOR IGF-1 IN THE RESCUE OF CNS NEURONS FOLLOWING HYPOXIC-ISCHEMIC INJURY

被引：359

作者：

GLUCKMAN, P ^{[1
]}

KLEMPT, N ^{[1
]}

GUAN, J ^{[1
]}

MALLARD, C ^{[1
]}

SIRIMANNE, E ^{[1
]}

DRAGUNOW, M ^{[1
]}

KLEMPT, M ^{[1
]}

SINGH, K ^{[1
]}

WILLIAMS, C ^{[1
]}

NIKOLICS, K ^{[1
]}

机构：

[1] GENENTECH INC, DEPT NEUROSCI, SAN FRANCISCO, CA 94080 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 182卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91774-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three days after unilateral hypoxic-ischemic injury in infant rats insulin-like growth factor 1 (IGF-1) production by astrocytes was enhanced in the injured region. This was associated with increased expression of mRNA for IGF binding protein-3 but not for binding protein-1. In adult rats a single lateral cerebroventricular injection of IGF-1 two hours following a similar injury markedly reduced neuronal loss. It is suggested that endogenous IGF-1 is neurotrophic and that centrally administered IGF-1 may have therapeutic potential for brain injury. © 1992.

引用

页码：593 / 599

页数：7

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