POLYOL PATHWAY IN AORTA - REGULATION BY HORMONES

被引：122

作者：

CLEMENTS, RS

MORRISON, AD

WINEGRAD, AI

机构：

[1] George S. Cox Medical Research Institute, Department of Medicine, University of Pennsylvania, Philadelphia, PA

来源：

SCIENCE | 1969年 / 166卷 / 3908期

关键词：

D O I：

10.1126/science.166.3908.1007

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Aldose reductase is present in human and rabbit aortas and provides a mechanism whereby hyperglycemia can alter the metabolism of the arterial wall. Aortic sorbitol concentration is regulated by ambient glucose concentration and is increased by epinephrine, isoproterenol, dibutyryl-3′,5′- adenosine monophosphate, ouabain, and angiotensin II.

引用

页码：1007 / &

共 13 条

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