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LINKAGE DISEQUILIBRIUM AND RECOMBINATION MAKE A TELOMERIC SITE FOR THE HUNTINGTONS-DISEASE GENE UNLIKELY

被引：20
作者：
BARRON, L
CURTIS, A
SHRIMPTON, AE
HOLLOWAY, S
MAY, H
SNELL, RG
BROCK, DJH
机构：
[1] UNIV EDINBURGH,WESTERN GEN HOSP,HUMAN GENET UNIT,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND
[2] DUNCAN GUTHRIE INST MED GENET,GLASGOW,SCOTLAND
[3] UNIV WALES COLL MED,INST MED GENET,CARDIFF CF4 4XN,S GLAM,WALES
来源：
JOURNAL OF MEDICAL GENETICS | 1991年 / 28卷 / 08期
关键词：
D O I：
10.1136/jmg.28.8.520
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
In a Scottish family in which Huntington's disease (HD) was segregating, recombination was observed between the D4S115/S111 and D4S43/S95 loci, with the HD gene associated with the more proximal D4S43/S95 locus. Analysis of linkage disequilibrium in Scottish families showed significant non-random association between the HD gene and alleles at the D4S95 and D4S98 loci. This adds to previous evidence that the HD locus is not sited at the telomere of chormosome 4.
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页码：520 / 522
页数：3
相关论文
共 13 条
[1]  
BATES GP, 1990, AM J HUM GENET, V46, P762
[2]  
BUCAN M, 1990, GENOMICS, V6, P1
[3]   THE HUNTINGTON DISEASE LOCUS IS MOST LIKELY WITHIN 325 KILOBASES OF THE CHROMOSOME-4P TELOMERE [J].
DOGGETT, NA ;
CHENG, JF ;
SMITH, CL ;
CANTOR, CR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (24) :10011-10014
[4]   A POLYMORPHIC DNA MARKER GENETICALLY LINKED TO HUNTINGTONS-DISEASE [J].
GUSELLA, JF ;
WEXLER, NS ;
CONNEALLY, PM ;
NAYLOR, SL ;
ANDERSON, MA ;
TANZI, RE ;
WATKINS, PC ;
OTTINA, K ;
WALLACE, MR ;
SAKAGUCHI, AY ;
YOUNG, AB ;
SHOULSON, I ;
BONILLA, E ;
MARTIN, JB .
NATURE, 1983, 306 (5940) :234-238
[5]  
MCDONALD ME, 1989, J CLIN INVEST, V84, P1013
[6]  
MCDONALD ME, 1990, NEURON, V3, P183
[7]   A CLONED DNA SEGMENT FROM THE TELOMERIC REGION OF HUMAN CHROMOSOME-4P IS NOT DETECTABLY REARRANGED IN HUNTINGTON DISEASE PATIENTS [J].
PRITCHARD, C ;
CASHER, D ;
BULL, L ;
COX, DR ;
MYERS, RM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (18) :7309-7313
[8]  
ROBBINS C, 1989, AM J HUM GENET, V44, P422
[9]   LINKAGE DISEQUILIBRIUM IN HUNTINGTONS-DISEASE - AN IMPROVED LOCALIZATION FOR THE GENE [J].
SNELL, RG ;
LAZAROU, LP ;
YOUNGMAN, S ;
QUARRELL, OWJ ;
WASMUTH, JJ ;
SHAW, DJ ;
HARPER, PS .
JOURNAL OF MEDICAL GENETICS, 1989, 26 (11) :673-675
[10]   NON-RANDOM ASSOCIATION BETWEEN ALLELES DETECTED AT D4S95 AND D4S98 AND THE HUNTINGTONS-DISEASE GENE [J].
THEILMANN, J ;
KANANI, S ;
SHIANG, R ;
ROBBINS, C ;
QUARRELL, O ;
HUGGINS, M ;
HEDRICK, A ;
WEBER, B ;
COLLINS, C ;
WASMUTH, JJ ;
BUETOW, KH ;
MURRAY, JC ;
HAYDEN, MR .
JOURNAL OF MEDICAL GENETICS, 1989, 26 (11) :676-681
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