EFFECTS OF SULFONATE ANIONS ON THE SELF-ASSEMBLY OF BRAIN TUBULIN

被引：18

作者：

HIMES, RH ^{[1
]}

NEWHOUSE, CS ^{[1
]}

HASKINS, KM ^{[1
]}

BURTON, PR ^{[1
]}

机构：

[1] UNIV KANSAS,DEPT PHYSIOL & CELL BIOL,LAWRENCE,KS 66045

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 87卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0006-291X(79)80011-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sulfonate buffers and aliphatic sulfonate salts influence the formation of microtubules in vitro in a manner that is not explained on the basis of ionic strength. Their presence stimulates assembly at higher pH values causing a broadening of the pH optimum curve. Assembly can occur in very high concentrations of sulfonate salts, at ionic strengths which inhibit assembly in the absence of these compounds. The effectiveness of the aliphatic sulfonate compounds is altered as the chain length is increased. Dimethylsulfoxide has an additional effect and influences the structure of the polymerized product. © 1979 Academic Press, Inc. All rights of reproduction in any form reserved.

引用

页码：1031 / 1038

页数：8

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