ROLE OF HYPERTONICITY IN THE ENDOTHELIAL INJURY CAUSED BY ANGIOGRAPHIC CONTRAST-MEDIA

被引：39

作者：

RAININKO, R

机构：

[1] DEPARTMENT OF DIAGNOSTIC RADIOLOGY, TURKU UNIVERSITY HOSPITAL

来源：

ACTA RADIOLOGICA-DIAGNOSIS | 1979年 / 20卷 / 03期

关键词：

D O I：

10.1177/028418517902000302

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The effect of hyperosmolality on the permeability of vascular endothelium was investigated using light microscopy and silver staining of the thoracic aorta in the rat. The threshold osmolality causing significant endothelial injury was 1.41 to 1.59 tested with sodium chloride solutions. The osmolalities of ionic contrast media in clinical concentrations were at or over the osmotic threshold. Most angiographic contrast media injured the endothelium more than equiosmolal sodium chloride solutions. Hyperosmolality is only one factor contributing to the increased endothelial permeability. © 1979, The Foundation Acta Radiologica. All rights reserved.

引用

页码：410 / 416

页数：7

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