STUDIES ON RNA FROM AVIAN MYELOBLASTOSIS VIRUS

RNA from avian myeloblastosis virus was purified and some of its properties were examined. Two RNA components were isolated from the virus. Based on the amount of methylation of the RNA and on its base ratios the small component, which sediments at 4 S, appears to be similar to host cell transfer RNA. The large component behaves like a high molecular weight single-stranded RNA based on sedimentation properties and is apparently not methylated. However, when this component is heated above 70° it dissociates to a 35 S component(s) which under appropriate conditions is the only detectable breakdown product. © 1969.