LESIONS OF CENTRAL NOREPINEPHRINE TERMINALS WITH 6-OH-DOPAMINE - BIOCHEMISTRY AND FINE STRUCTURE

被引：413

作者：

BLOOM, FE

ALGERI, S

GROPPETTI, A

REVUELTA, A

COSTA, E

机构：

[1] Laboratories of Neuropharmacology and Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington

来源：

SCIENCE | 1969年 / 166卷 / 3910期

关键词：

D O I：

10.1126/science.166.3910.1284

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Intracisternal injections of 6-hydroxydopamine produce rapid and long-lasting depletion of brain catecholamines without effects on serotonin concentrations. Depletion of norepinephrine is greatest in areas containing only nerve terminals and axons and least in areas containing monoamine cell bodies. The norepinephrine loss is accompanied by electron microscopic evidence of nerve terminal degeneration and decreased turnover. Dopamine loss is less marked and is not accompanied by degeneration or alteration of turnover rate.

引用

页码：1284 / +

页数：1

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