MOLECULAR CONTROL OF LIFE AND DEATH

被引：88

作者：

YUAN, JY ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,BOSTON,MA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1995年 / 7卷 / 02期

关键词：

D O I：

10.1016/0955-0674(95)80030-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent evidence has shown that two of the three key genes in the programmed cell death pathway of Caenorhabditis elegans, ced-9 (a cell death suppressor) and ced-3 (a cell death inducer), encode proteins that share structural and functional similarities with the mammalian proto-oncogene product Bcl-2 and interleukin-1 beta converting enzyme, respectively. These findings reveal key molecules that control lire and death decisions in vertebrates.

引用

收藏

页码：211 / 214

页数：4

相关论文

共 35 条

[1] CLONING THE CHROMOSOMAL BREAKPOINT OF T(14-18) HUMAN LYMPHOMAS - CLUSTERING AROUND JH ON CHROMOSOME-14 AND NEAR A TRANSCRIPTIONAL UNIT ON 18 [J].

BAKHSHI, A ;

JENSEN, JP ;

GOLDMAN, P ;

WRIGHT, JJ ;

MCBRIDE, OW ;

EPSTEIN, AL ;

KORSMEYER, SJ .

CELL, 1985, 41 (03) :899-906

[2] BCL-X, A BCL-2-RELATED GENE THAT FUNCTIONS AS A DOMINANT REGULATOR OF APOPTOTIC CELL-DEATH [J].

BOISE, LH ;

GONZALEZGARCIA, M ;

POSTEMA, CE ;

DING, LY ;

LINDSTEN, T ;

TURKA, LA ;

MAO, XH ;

NUNEZ, G ;

THOMPSON, CB .

CELL, 1993, 74 (04) :597-608

[3] MOLECULAR-CLONING OF THE INTERLEUKIN-1-BETA CONVERTING ENZYME [J].

CERRETTI, DP ;

KOZLOSKY, CJ ;

MOSLEY, B ;

NELSON, N ;

VANNESS, K ;

GREENSTREET, TA ;

MARCH, CJ ;

KRONHEIM, SR ;

DRUCK, T ;

CANNIZZARO, LA ;

HUEBNER, K ;

BLACK, RA .

SCIENCE, 1992, 256 (5053) :97-100

[4] CLONING AND STRUCTURAL-ANALYSIS OF CDNAS FOR BCL-2 AND A HYBRID BCL-2/IMMUNOGLOBULIN TRANSCRIPT RESULTING FROM THE T(14-18) TRANSLOCATION [J].

CLEARY, ML ;

SMITH, SD ;

SKLAR, J .

CELL, 1986, 47 (01) :19-28

[5]

DIGIOVINE FS, 1990, IMMUNOL TODAY, V11, P13

[6]

DINARELLO CA, 1991, BLOOD, V77, P1627

[7] GENETIC-CONTROL OF PROGRAMMED CELL-DEATH IN THE NEMATODE C-ELEGANS [J].

ELLIS, HM ;

HORVITZ, HR .

CELL, 1986, 44 (06) :817-829

[8] MECHANISMS AND FUNCTIONS OF CELL-DEATH [J].

ELLIS, RE ;

YUAN, JY ;

HORVITZ, HR .

ANNUAL REVIEW OF CELL BIOLOGY, 1991, 7 :663-698

[9]

FERNANDESALNEMR.T, 1994, J BIOL CHEM, V269, P30761

[10] PREVENTION OF VERTEBRATE NEURONAL DEATH BY THE CRMA GENE [J].

GAGLIARDINI, V ;

FERNANDEZ, PA ;

LEE, RKK ;

DREXLER, HCA ;

ROTELLO, RJ ;

FISHMAN, MC ;

YUAN, J .

SCIENCE, 1994, 263 (5148) :826-828

← 1 2 3 4 →