THE DEFECTIVE GENE IN X-LINKED SEVERE COMBINED IMMUNODEFICIENCY ENCODES A SHARED INTERLEUKIN RECEPTOR SUBUNIT - IMPLICATIONS FOR CYTOKINE PLEIOTROPY AND REDUNDANCY

被引：52

作者：

LEONARD, WJ

机构：

[1] National Institutes of Health, Bethesda

来源：

CURRENT OPINION IN IMMUNOLOGY | 1994年 / 6卷 / 04期

关键词：

D O I：

10.1016/0952-7915(94)90152-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The interleukin-2 receptor plays a pivotal role in the regulation of the normal T cell immune response to foreign antigen. The IL-2 receptor gamma-chain is one component of this receptor, and is encoded by the gene that is defective in X-linked severe combined immunodeficiency. The clinical manifestations of this disease led to the hypothesis and subsequent confirmation that the gamma-chain was in fact a subunit shared by multiple cytokine receptors, including those for IL-2, IL-4, and IL-7.

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页码：631 / 635

页数：5

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