CHARACTERIZATION OF MUSCARINIC ACETYLCHOLINE-RECEPTORS IN HUMAN LABIAL SALIVARY-GLANDS

被引：27

作者：

MEI, L

ROESKE, WR

IZUTSU, KT

YAMAMURA, HI

机构：

[1] UNIV ARIZONA,ARIZONA HLTH SCI CTR,COLL MED,DEPT PHARMACOL,TUCSON,AZ 85724

[2] UNIV ARIZONA,ARIZONA HLTH SCI CTR,DEPT BIOCHEM,TUCSON,AZ 85724

[3] UNIV ARIZONA,ARIZONA HLTH SCI CTR,DEPT PSYCHIAT,TUCSON,AZ 85724

[4] UNIV WASHINGTON,DEPT ORAL BIOL,SEATTLE,WA 98195

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 176卷 / 03期

关键词：

Labial salivary gland (human); Muscarinic receptor antagonists; Muscarinic receptor subtypes;

D O I：

10.1016/0014-2999(90)90032-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Muscarinic acetylcholine receptors were studied in human labial salivary glands with (-)-[3H]MQNB. The radioligand bound with a Kd value of 150 pM. The density of muscarinic receptors was 220 fmol/mg protein. Most muscarinic antagonists bound to a homogenous population of muscarinic receptors in this tissue. However, the inhibition curves of pirenzepine had a Hill slope of 0.57 and could be analyzed by a two site model. These results suggest that the muscarinic receptors in human labial salivary glands are a mixture of M1 and M3 types. © 1990.

引用

页码：367 / 370

页数：4

共 10 条

[1] HETEROGENEITY OF THE M1 MUSCARINIC RECEPTOR SUBTYPE BETWEEN PERIPHERAL LUNG AND CEREBRAL-CORTEX DEMONSTRATED BY THE SELECTIVE ANTAGONIST AF-DX 116 [J].