EXPRESSION OF A ZINC FINGER GENE IN HTLV-I AND HTLV-II TRANSFORMED-CELLS

被引：74

作者：

WRIGHT, JJ

GUNTER, KC

MITSUYA, H

IRVING, SG

KELLY, K

SIEBENLIST, U

机构：

[1] NIAID, IMMUNOREGULAT LAB, BETHESDA, MD 20892 USA

[2] NCI, MED BRANCH, BETHESDA, MD 20892 USA

[3] NCI, PATHOL LAB, BETHESDA, MD 20892 USA

[4] NCI, CLIN ONCOL PROGRAM, BETHESDA, MD 20892 USA

来源：

SCIENCE | 1990年 / 248卷 / 4955期

关键词：

D O I：

10.1126/science.2110381

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Gene products encoded by the human T cell leukemia virus (HTLV) types I and II mediate transformation by the transactivation of cellular genes necessary for proliferation, probably including transcriptional regulatory factors. By searching for factors that may control proliferation, a zinc finger gene (225) was identified that was constitutively expressed in all HTLV-I- or HTLV-II-transformed cell lines examined, whereas in normal T cells it was only transiently expressed after mitogenic stimulation. The 225 gene was also constitutively expressed in two HTLV-I-transformed helper T cell clones, but not in the parental cell lines. Thus this putative cellular transcriptional factor, which was abnormally expressed in retrovirus-infected cells, may have a role in transformation.

引用

页码：588 / 591

页数：4

共 56 条

[1] THE C-TERMINAL DOMAIN OF THE LARGEST SUBUNIT OF RNA POLYMERASE-II OF SACCHAROMYCES-CEREVISIAE, DROSOPHILA-MELANOGASTER, AND MAMMALS - A CONSERVED STRUCTURE WITH AN ESSENTIAL FUNCTION [J].