SOLID-PHASE PEPTIDE-SYNTHESIS UTILIZING 9-FLUORENYLMETHOXYCARBONYL AMINO-ACIDS

被引：2357

作者：

FIELDS, GB ^{[1
]}

NOBLE, RL ^{[1
]}

机构：

[1] APPL BIOSYST INC,FOSTER CITY,CA

来源：

INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH | 1990年 / 35卷 / 03期

关键词：

9‐fluorenylmethoxycarbonyl amino acids; peptide linkages; solid phase peptide synthesis;

D O I：

10.1111/j.1399-3011.1990.tb00939.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

9‐Fluorenylmethoxycarbonyl (Fmoc) amino acids were first used for solid phase peptide synthesis a little more than a decade ago. Since that time, Fmoc solid phase peptide synthesis methodology has been greatly enhanced by the introduction of a variety of solid supports, linkages, and side chain protecting groups, as well as by increased understanding of solvation conditions. These advances have led to many impressive syntheses, such as those of biologically active and isotopically labeled peptides and small proteins. The great variety of conditions under which Fmoc solid phase peptide synthesis may be carried out represents a truly “orthogonal” scheme, and thus offers many unique opportunities for bioorganic chemistry. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：161 / 214

页数：54

共 737 条

[1] BASE-CATALYZED FORMATION OF CYCLIC COMPOUNDS FROM POLY-BETA-BENZYL-L-ASPARTATE AND POLY-GAMMA-BENZYL-L-GLUTAMATE [J].