MEDICAL HISTORY AND THE RISK OF ALZHEIMERS-DISEASE - A COLLABORATIVE REANALYSIS OF CASE-CONTROL STUDIES

被引：159

作者：

BRETELER, MMB

VANDUIJN, CM

CHANDRA, V

FRATIGLIONI, L

GRAVES, AB

HEYMAN, A

JORM, AF

KOKMEN, E

KONDO, K

MORTIMER, JA

ROCCA, WA

SHALAT, SL

SOININEN, H

HOFMAN, A

机构：

[1] Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam

[2] EURODEM and Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam

来源：

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY | 1991年 / 20卷

关键词：

D O I：

10.1093/ije/20.Supplement_2.S36

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

In a re-analysis of eight case-control studies on Alzheimer's disease we explored several medical conditions that had previously been suggested as possible risk factors for Alzheimer's disease. History of hypothyroidism was increased in cases as compared to controls (relative risk 2.3; 95% confidence interval 1.0-5.4). Severe headaches and migraine were inversely related to Alzheimer's disease (relative risk 0.7; 95% confidence interval 0.5-1.0). More cases than controls reported epilepsy before onset of Alzheimer's disease (relative risk 1.6; 95% confidence interval 0.7-3.5), especially for epilepsy with an onset within 10 years of onset of dementia. Neurotropic viruses, allergic conditions, general anaesthesia and blood transfusions were not associated with Alzheimer's disease.

引用

页码：S36 / S42

页数：7

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[1] WHAT IS THE NATURE OF THE ROLE OF THE SEROTONERGIC NERVOUS-SYSTEM IN LEARNING AND MEMORY - PROSPECTS FOR DEVELOPMENT OF AN EFFECTIVE TREATMENT STRATEGY FOR SENILE DEMENTIA [J].