DIFFERENTIATION OF ENDOTHELIUM

被引：480

作者：

RISAU, W

机构：

[1] Max-Planck-Inst. P.K.F., W. G. Kerckhoff Institut, Abteilung Molekulare Zellbiologie

[2] Max-Planck-Inst. P.K.F., W. G. Kerckhoff Institut, Abteilung Molekulare Zellbiologie, D-61231 Bad Nauheim

来源：

FASEB JOURNAL | 1995年 / 9卷 / 10期

关键词：

ENDOTHELIAL CELLS; VASCULAR REGRESSION; CELL SURFACE MOLECULES; BLOOD-BRAIN BARRIER;

D O I：

10.1096/fasebj.9.10.7615161

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vascular endothelial cells cover the entire inner surface of blood vessels in the body, They play an important role in tissue homeostasis, fibrinolysis and coagulation, blood-tissue exchange, vasotonus regulation, the vascularization of normal and neoplastic tissues, and blood cell activation and migration during physiological and pathological processes, It is therefore important to define the basic: determinants of the endothelial phenotype and its modulation in response to different signals, Signal recognition, transduction, and processing are likely to be complex events dependent on the status of the target endothelial cell in a given organ or tissue, This status is a consequence of inductive and permissive interactions of a pluripotent cell with soluble and insoluble signaling molecules of the environment during embryonic and postnatal development, This review will focus on the biological mechanisms involved in the differentiation of endothelial cells from the mesoderm and their subsequent functional heterogeneity in different organs and tissues under physiological as well as pathological conditions.

引用

页码：926 / 933

页数：8

共 92 条

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