HYPOTHALAMIC WARM-SENSITIVE NEURONS POSSESS A TETRODOTOXIN-SENSITIVE SODIUM-CHANNEL WITH A HIGH Q10

被引：43

作者：

KIYOHARA, T ^{[1
]}

HIRATA, M ^{[1
]}

HORI, T ^{[1
]}

AKAIKE, N ^{[1
]}

机构：

[1] TOHOKU UNIV,SCH MED,DEPT NEUROPHYSIOL,SENDAI,MIYAGI 980,JAPAN

来源：

NEUROSCIENCE RESEARCH | 1990年 / 8卷 / 01期

关键词：

Dissociated cell; Hypothalamus; TTX-sensitive; non-inactivated sodium current; Warm-sensitive neuron; Whole-cell clamp;

D O I：

10.1016/0168-0102(90)90056-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have investigated the ionic current responses to temperature of dissociated cells from the preoptic and anterior hypothalamus (PO/AH) of rat, using the 'whole-cell' configuration. The majority of the recorded neurons showed a linear increase in a non-inactivating inward current during warming (30-40°C), and the Q10 was about 2. However, about 24% of PO/AH neurons were markedly sensitive to warming and the increase in non-inactivating inward current to a rise in temperature in the hyperthermic range (35-40°C) had a high Q10 (4.3-7.0). This increase in current in the hyperthermic range was reversibly blocked by tetrodotoxin (TTX). The inward current in neurons with a Q10 of 2 was not affected by TTX. The results show that some neurons in the PO/AH possess a non-inactivating sodium channel that is highly temperature-sensitive in the hyperthermic range. These neurons are presumably the 'primary' warm-sensitive neurons. © 1990.

引用

页码：48 / 53

页数：6

共 22 条

[1] CONCENTRATION-CLAMP STUDY OF GAMMA-AMINOBUTYRIC-ACID-INDUCED CHLORIDE CURRENT KINETICS IN FROG SENSORY NEURONS [J].

AKAIKE, N ;

INOUE, M ;

KRISHTAL, OA .

JOURNAL OF PHYSIOLOGY-LONDON, 1986, 379 :171-185

[2]

[Anonymous], 1981, THERMORECEPTION TEMP

[3] ELECTRO-PHYSIOLOGICAL ANALYSIS OF NEURONAL THERMOSENSITIVITY IN RAT PREOPTIC AND HYPOTHALAMIC TISSUE-CULTURES [J].

BALDINO, F ;

GELLER, HM .

JOURNAL OF PHYSIOLOGY-LONDON, 1982, 327 (JUN) :173-184

[4]

Boulant J., 1980, HDB HYPOTHALAMUS A, V3A, P1

[5] TILIQUA SCINCOIDES - TEMPERATURE-SENSITIVE UNITS IN LIZARD BRAIN [J].

CABANAC, M ;

HAMMEL, T ;

HARDY, JD .

SCIENCE, 1967, 158 (3804) :1050-&

[6]

CARPENTER DO, 1981, FED PROC, V40, P2808

[7] A THRESHOLD SODIUM CURRENT IN PYRAMIDAL CELLS IN RAT HIPPOCAMPUS [J].

FRENCH, CR ;

GAGE, PW .

NEUROSCIENCE LETTERS, 1985, 56 (03) :289-293

[8] THRESHOLD CHANNELS - A NOVEL TYPE OF SODIUM-CHANNEL IN SQUID GIANT-AXON [J].

GILLY, WF ;

ARMSTRONG, CM .

NATURE, 1984, 309 (5967) :448-450

[9] CHARACTERIZATION OF RESPONSES FROM TEMPERATURE-SENSITIVE UNITS IN TROUT BRAIN [J].

GREER, GL ;

GARDNER, DR .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY, 1974, 48 (1A) :189-203

[10] MULTIMODAL RESPONSES OF PREOPTIC AND ANTERIOR HYPOTHALAMIC NEURONS TO THERMAL AND NONTHERMAL HOMEOSTATIC PARAMETERS [J].

HORI, T ;

KIYOHARA, T ;

NAKASHIMA, T ;

SHIBATA, M ;

KOGA, H .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1987, 65 (06) :1290-1298

← 1 2 3 →