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A POTENT METABOTROPIC GLUTAMATE RECEPTOR AGONIST - ELECTROPHYSIOLOGICAL ACTIONS OF A CONFORMATIONALLY RESTRICTED GLUTAMATE ANALOG IN THE RAT SPINAL-CORD AND XENOPUS OOCYTES

被引：81
作者：
ISHIDA, M
AKAGI, H
SHIMAMOTO, K
OHFUNE, Y
SHINOZAKI, H
机构：
[1] TOKYO METROPOLITAN INST MED SCI,3-18-22 HONKOMAGOME,BUNKYO KU,TOKYO 113,JAPAN
[2] SUNTORY INST BIOORGAN RES,OSAKA,JAPAN
[3] MITSUBISHI KASEI INST LIFE SCI,DEPT NEUROSCI,TOKYO,JAPAN
来源：
BRAIN RESEARCH | 1990年 / 537卷 / 1-2期
关键词：
GLUTAMATE; ALPHA-(CARBOXYCYCLOPROPYL)GLYCINE; RAT SPINAL CORD; MESSENGER RNA; METABOTROPIC RECEPTOR; XENOPUS OOCYTE;
D O I：
10.1016/0006-8993(90)90375-L
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The (2S,3S,4S) isomer of alpha-(carboxycyclopropyl)glycine (L-CCG-I), a conformationally restricted glutamate analogue, caused a marked depolarization of motoneurons in the isolated rat spinal cord, which was almost insensitive to CPP and CNQX. Depolarizing responses to L-CCG-I were markedly decreased by reducing the temperature of the bathing fluid. Similar results were obtained in the case of trans-ACPD, which is a metabotropic glutamate receptor agonist, but the depolarizing action of L-CCG-I was more potent than that of trans-ACPD. In Xenopus oocytes injected with poly(A)+ mRNA extracted from the rat brain, L-CCG-I induced significantly oscillatory chloride currents, suggesting that L-CCG-I is a potent agonist for metabotropic-type glutamate receptors.
引用
收藏
页码：311 / 314
页数：4
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