NITRIC-OXIDE DONORS INCREASE MUCUS GEL THICKNESS IN RAT STOMACH

被引：147

作者：

BROWN, JF

HANSON, PJ

WHITTLE, BJR

机构：

[1] WELLCOME RES LABS,DEPT PHARMACOL,LANGLEY COURT,BECKENHAM BR3 3BS,KENT,ENGLAND

[2] UNIV ASTON,INST PHARMACEUT SCI,BIRMINGHAM B4 7ET,W MIDLANDS,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 223卷 / 01期

关键词：

NITRIC OXIDE (NO); MUCUS; GASTRIC MUCOSA;

D O I：

10.1016/0014-2999(92)90824-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Instillation of the nitric oxide (NO) generator isosorbide dinitrate (0.1-1 mM) into the rat gastric lumen in vivo produced a dose-related increase in mucus gel thickness that was prevented by coadministration of oxyhaemoglobin (10 muM). Isosorbide dinitrate did not induce epithelial cell damage. S-Nitroso-N-acetyl penicillamine (0.3 mM) and dibutyryl cyclic GMP (1 mM) also increased mucus thickness. These findings, along with the presence of NO synthase in the gastric mucosa, imply a role for NO in vivo in mediation of gastric mucus release.

引用

页码：103 / 104

页数：2

共 6 条

[1]

ALLEN A, 1989, ADV DRUG THERAPY GAS, P139

[2] DIFFERENTIAL DISTRIBUTION OF NITRIC-OXIDE SYNTHASE BETWEEN CELL-FRACTIONS ISOLATED FROM THE RAT GASTRIC-MUCOSA [J].