CONTRAST-ENHANCED NMR IMAGING - ANIMAL STUDIES USING GADOLINIUM-DTPA COMPLEX

被引:356
作者
BRASCH, RC
WEINMANN, HJ
WESBEY, GE
机构
[1] UNIV CALIF SAN FRANCISCO, SCH MED, DEPT RADIOL, SAN FRANCISCO, CA 94143 USA
[2] SCHERING AG, RES LABS, D-1000 BERLIN 65, FED REP GER
关键词
D O I
10.2214/ajr.142.3.625
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Gd-DTPA [diethylenetriaminepentaacetic acid] complex was assessed as NMR contrast-enhancing agent by experimentally imaging normal and diseased animals. After i.v. injection, Gd-DTPA, a strongly paramagnetic complex by virtue of unpaired electrons, was rapidly excreted into the urine of rats, producing an easily observable contrast enhancement on NMR images in kidney parenchyma and urine. Spin-echo intensity of urine within the renal pelvis increased from 2263 to 4414 units; intensity of renal parenchyma increased from 2901 to 3893 after administration of 0.1 mmol/kg Gd-DTPA. Sterile soft-tissue abscesses demonstrated an obvious rim pattern of enhancement. A focus of radiation-induced brain damage in a canine model was only faintly detectable on spin-echo NMR images before contrast administration. After 0.5 mmol/kg Gd-DTPA administration, the lesion intensity increased from 3867 to 5590. In comparison, the normal brain with an intact blood-brain barrier remained unchanged in NMR characterization. Gd-DTPA is a promising new NMR contrast enhancer for the clinical assessment of renal function, inflammatory lesions and focal disruption of the blood-brain barrier.
引用
收藏
页码:625 / 630
页数:6
相关论文
共 14 条
[1]   METHODS OF CONTRAST ENHANCEMENT FOR NMR IMAGING AND POTENTIAL APPLICATIONS - A SUBJECT REVIEW [J].
BRASCH, RC .
RADIOLOGY, 1983, 147 (03) :781-788
[2]   NUCLEAR MAGNETIC-RESONANCE STUDY OF A PARAMAGNETIC NITROXIDE CONTRAST AGENT FOR ENHANCEMENT OF RENAL STRUCTURES IN EXPERIMENTAL-ANIMALS [J].
BRASCH, RC ;
LONDON, DA ;
WESBEY, GE ;
TOZER, TN ;
NITECKI, DE ;
WILLIAMS, RD ;
DOEMENY, J ;
TUCK, LD ;
LALLEMAND, DP .
RADIOLOGY, 1983, 147 (03) :773-779
[3]   NUCLEAR MAGNETIC-RESONANCE WHOLE-BODY IMAGER OPERATING AT 3.5 KGAUSS [J].
CROOKS, L ;
ARAKAWA, M ;
HOENNINGER, J ;
WATTS, J ;
MCREE, R ;
KAUFMAN, L ;
DAVIS, PL ;
MARGULIS, AR ;
DEGROOT, J .
RADIOLOGY, 1982, 143 (01) :169-174
[4]   TOMOGRAPHY OF HYDROGEN WITH NUCLEAR MAGNETIC-RESONANCE [J].
CROOKS, L ;
HOENNINGER, J ;
ARAKAWA, M ;
KAUFMAN, L ;
MCREE, R ;
WATTS, J ;
SINGER, JH .
RADIOLOGY, 1980, 136 (03) :701-706
[5]   RELAXATION ENHANCEMENT BY PARAMAGNETIC ION BINDING IN DEOXYRIBONUCLEIC ACID SOLUTIONS [J].
EISINGER, J ;
SHULMAN, RG ;
BLUMBERG, WE .
NATURE, 1961, 192 (480) :963-&
[6]  
FIKE JR, 1982, RADIAT RES, V91, P370
[7]   INVIVO IMAGING OF THE RAT ANATOMY WITH NUCLEAR MAGNETIC-RESONANCE [J].
HANSEN, G ;
CROOKS, LE ;
DAVIS, P ;
DEGROOT, J ;
HERFKENS, R ;
MARGULIS, AR ;
GOODING, C ;
KAUFMAN, L ;
HOENNINGER, J ;
ARAKAWA, M ;
MCREE, R ;
WATTS, J .
RADIOLOGY, 1980, 136 (03) :695-700
[8]   NUCLEAR MAGNETIC-RESONANCE IMAGING OF THE ABNORMAL LIVE RAT AND CORRELATIONS WITH TISSUE CHARACTERISTICS [J].
HERFKENS, R ;
DAVIS, P ;
CROOKS, L ;
KAUFMAN, L ;
PRICE, D ;
MILLER, T ;
MARGULIS, AR ;
WATTS, J ;
HOENNINGER, J ;
ARAKAWA, M ;
MCREE, R .
RADIOLOGY, 1981, 141 (01) :211-218
[9]   PARAMAGNETIC CONTRAST AGENTS IN NUCLEAR MAGNETIC-RESONANCE MEDICAL IMAGING [J].
MENDONCADIAS, MH ;
GAGGELLI, E ;
LAUTERBUR, PC .
SEMINARS IN NUCLEAR MEDICINE, 1983, 13 (04) :364-376
[10]  
MOELLER T, 1980, GMELIN HDB ANORGA D1