AMINO-ACID SUBSTITUTION MATRICES FROM PROTEIN BLOCKS

被引：4353

作者：

HENIKOFF, S

HENIKOFF, JG

机构：

[1] Basic Sciences Division, Fred Hutchinson Cancer Research Ctr., Howard Hughes Medical Institute, Seattle

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 22期

关键词：

AMINO ACID SEQUENCE; ALIGNMENT ALGORITHMS; DATA BASE SEARCHING;

D O I：

10.1073/pnas.89.22.10915

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Methods for alignment of protein sequences typically measure similarity by using a substitution matrix with scores for all possible exchanges of one amino acid with another. The most widely used matrices are based on the Dayhoff model of evolutionary rates. Using a different approach, we have derived substitution matrices from about 2000 blocks of aligned sequence segments characterizing more than 500 groups of related proteins. This led to marked improvements in alignments and in searches using queries from each of the groups.

引用

页码：10915 / 10919

页数：5

共 26 条

[1]

AMINO-ACID SUBSTITUTION MATRICES FROM AN INFORMATION THEORETIC PERSPECTIVE [J].