NEOCORTICAL DAMAGE DURING HIV-INFECTION

被引：441

作者：

WILEY, CA ^{[1
]}

MASLIAH, E ^{[1
]}

MOREY, M ^{[1
]}

LEMERE, C ^{[1
]}

DETERESA, R ^{[1
]}

GRAFE, M ^{[1
]}

HANSEN, L ^{[1
]}

TERRY, R ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT NEUROSCI,LA JOLLA,CA 92093

来源：

ANNALS OF NEUROLOGY | 1991年 / 29卷 / 06期

关键词：

D O I：

10.1002/ana.410290613

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Clinical and pathological evidence of subcortical central nervous system (CNS) damage is observed commonly in patients with human immunodeficiency virus (HIV) encephalitis. Whether other CNS regions are also affected has not been well studied. We report neocortical damage in patients with HIV encephalitis. Using quantitative techniques, we demonstrate statistically significant thinning of the neocortex, with a loss of large cortical neurons. Qualitative and quantitative assessments of neocortical neuropil reveal a loss of synaptic density and vacuolation of dendritic processes. Failure to demonstrate an association of these changes with the presence of HIV antigens suggests that neocortical damage may be an indirect effect of HIV infection of the CNS.

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页码：651 / 657

页数：7

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