STIMULATED PLATELETS RELEASE AMYLOID BETA-PROTEIN PRECURSOR

被引：80

作者：

COLE, GM

GALASKO, D

SHAPIRO, IP

SAITOH, T

机构：

[1] Department of Neurosciences, M-024 University of California at San Diego, La Jolla

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 170卷 / 01期

关键词：

D O I：

10.1016/0006-291X(90)91272-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human platelets can be stimulated by thrombin or ionomycin to secrete soluble truncated amyloid β-protein precursor and particulate membrane fragments which contain C-terminal and N-terminal immunoreactive reactive amyloid β-protein precursor. This suggests a possible circulating source of β-protein in serum which may play a role in the formation of amyloid deposits. The release of soluble amyloid β-protein precursor could be involved in normal platelet physiology. © 1990.

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页码：288 / 295

页数：8

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