DIFFERENTIAL EXPRESSION OF LOW-MOLECULAR-WEIGHT FORM OF GS-ALPHA IN NEOSTRIATUM AND CEREBELLUM - CORRELATION WITH EXPRESSION OF CALMODULIN-INDEPENDENT ADENYLYL CYCLASE

被引：27

作者：

COOPER, DMF

BOYAJIAN, CL

GOLDSMITH, PK

UNSON, CG

SPIEGEL, A

机构：

[1] ROCKEFELLER UNIV,DEPT BIOCHEM,NEW YORK,NY 10021

[2] NIDDKD,MOLEC PATHOPHYSIOL BRANCH,BETHESDA,MD 20892

来源：

BRAIN RESEARCH | 1990年 / 523卷 / 01期

关键词：

Adenylyl cyclase; Calcium ion; Calmodulin; Caudate-putamen; Cerebellum; G-protein; Neostriatum; Rat;

D O I：

10.1016/0006-8993(90)91648-Z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adenylyl cyclase of neostriatal plasma membranes is far less responsive to stimulation by Ca2+/calmodulin than is the enzyme from cerebellum. When these tissues were investigated with antibodies against known G-proteins, no difference could be detected in any G-protein species, other than Gs. Whereas the cerebellum expressed predominantly the large form of Gs-α, the neostriatum expressed mainly lower molecular weight forms. The possibility is considered that there is selective association between lower molecular weight forms of Gs and calmodulin-independent forms of adenylyl cyclase. © 1990.

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页码：143 / 146

页数：4

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