LITHIUM-SENSITIVE PRODUCTION OF INOSITOL PHOSPHATES DURING AMPHIBIAN EMBRYONIC MESODERM INDUCTION

被引：88

作者：

MASLANSKI, JA ^{[1
]}

LESHKO, L ^{[1
]}

BUSA, WB ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV, DEPT BIOL, BALTIMORE, MD 21218 USA

来源：

SCIENCE | 1992年 / 256卷 / 5054期

关键词：

D O I：

10.1126/science.1314424

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mesoderm induction and body axis determination in frog (Xenopus) embryos are thought to involve growth factor-mediated cell-cell signaling, but the signal transduction pathways are unknown. Li+, which inhibits the polyphosphoinositide (PI) cycle signal transduction pathway in many cells, also disrupts axis determination and mesoderm induction. Amounts of the PI cycle-derived second messenger, inositol 1,4,5-trisphosphate, increased during mesoderm induction in normal embryos; addition of Li+ inhibited the embryonic inositol monophosphatase and reversed this increase. Embryonic PI cycle activity thus shows characteristics that indicate it may function in mesoderm induction and axis determination.

引用

页码：243 / 245

页数：3

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