EXPRESSION OF BETA-AMYLOID PRECURSOR PROTEIN IN AXONS OF PERIVENTRICULAR LEUKOMALACIA BRAINS

被引：39

作者：

ARAI, Y ^{[1
]}

DEGUCHI, K ^{[1
]}

MIZUGUCHI, M ^{[1
]}

TAKASHIMA, S ^{[1
]}

机构：

[1] NATL CTR NEUROL & PSYCHIAT,NATL INST NEUROSCI,DEPT MENTAL RETARDAT & BIRTH DEFECT RES,TOKYO,JAPAN

来源：

PEDIATRIC NEUROLOGY | 1995年 / 13卷 / 02期

关键词：

D O I：

10.1016/0887-8994(95)00149-A

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Human beta-amyloid precursor protein immunoreactivity was demonstrated in axonal swellings (spheroids) around periventricular leukomalacia (PVL) of neonates. Immunoreactive axons were found at the early, but not late stage of PVL. beta-Amyloid precursor protein immunoreactivity was homogeneous in damaged axons at the early stage of PVL manifesting microglial activation, concentrated at the center of axonal swellings at the subsequent stage manifesting astrogliosis, and undetectable at the terminal stage of cavitation or neovasculation. Immunostaining for beta-amyloid precursor protein was useful in localizing PVL lesions at their early stages.

引用

页码：161 / 163

页数：3

共 12 条

[1]

FRIEDE RL, 1987, DEV NEUROPATHOLOGY, P70

[2] BETA-AMYLOID PRECURSOR PROTEIN (BETA-APP) AS A MARKER FOR AXONAL INJURY AFTER HEAD-INJURY [J].

GENTLEMAN, SM ;

NASH, MJ ;

SWEETING, CJ ;

GRAHAM, DI ;

ROBERTS, GW .

NEUROSCIENCE LETTERS, 1993, 160 (02) :139-144

[3] THE PRECURSOR OF ALZHEIMERS-DISEASE AMYLOID-A4 PROTEIN RESEMBLES A CELL-SURFACE RECEPTOR [J].

KANG, J ;

LEMAIRE, HG ;

UNTERBECK, A ;

SALBAUM, JM ;

MASTERS, CL ;

GRZESCHIK, KH ;

MULTHAUP, G ;

BEYREUTHER, K ;

MULLERHILL, B .

NATURE, 1987, 325 (6106) :733-736

[4] PRECURSOR OF AMYLOID PROTEIN IN ALZHEIMER-DISEASE UNDERGOES FAST ANTEROGRADE AXONAL-TRANSPORT [J].

KOO, EH ;

SISODIA, SS ;

ARCHER, DR ;

MARTIN, LJ ;

WEIDEMANN, A ;

BEYREUTHER, K ;

FISCHER, P ;

MASTERS, CL ;

PRICE, DL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1561-1565

[5] BETA-AMYLOID PRECURSOR PROTEIN METABOLITES AND LOSS OF NEURONAL CA2+ HOMEOSTASIS IN ALZHEIMERS-DISEASE [J].

MATTSON, MP ;

BARGER, SW ;

CHENG, B ;

LIEBERBURG, I ;

SMITHSWINTOSKY, VL ;

RYDEL, RE .

TRENDS IN NEUROSCIENCES, 1993, 16 (10) :409-414

[6]

MORIN PJ, 1993, J NEUROCHEM, V61, P464

[7] ALZHEIMERS AMYLOID PRECURSOR PROTEIN ACCUMULATES WITHIN AXONAL SWELLINGS IN HUMAN BRAIN-LESIONS [J].

OHGAMI, T ;

KITAMOTO, T ;

TATEISHI, J .

NEUROSCIENCE LETTERS, 1992, 136 (01) :75-78

[8]

OTSUKA N, 1991, BRAIN RES, V586, P335

[9] SECRETED FORM OF AMYLOID-BETA PROTEIN-PRECURSOR IS INVOLVED IN THE GROWTH-REGULATION OF FIBROBLASTS [J].

SAITOH, T ;

SUNDSMO, M ;

ROCH, JM ;

KIMURA, N ;

COLE, G ;

SCHUBERT, D ;

OLTERSDORF, T ;

SCHENK, DB .

CELL, 1989, 58 (04) :615-622

[10] THE REGULATION OF AMYLOID-BETA-PROTEIN PRECURSOR SECRETION AND ITS MODULATORY ROLE IN CELL-ADHESION [J].

SCHUBERT, D ;

JIN, LW ;

SAITOH, T ;

COLE, G .

NEURON, 1989, 3 (06) :689-694

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