NEW STRUCTURE-ACTIVITY-RELATIONSHIPS OF THE QUINOLONE ANTIBACTERIALS USING THE TARGET ENZYME - THE DEVELOPMENT AND APPLICATION OF A DNA GYRASE ASSAY

被引:297
作者
DOMAGALA, JM
HANNA, LD
HEIFETZ, CL
HUTT, MP
MICH, TF
SANCHEZ, JP
SOLOMON, M
机构
关键词
D O I
10.1021/jm00153a015
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:394 / 404
页数:11
相关论文
共 49 条
[1]   STUDIES ON QUINOLINE DERIVATIVES AND RELATED COMPOUNDS .5. SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL 1-ALKOXY-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLIC ACIDS [J].
AGUI, H ;
MITANI, T ;
IZAWA, A ;
KOMATSU, T ;
NAKAGOME, T .
JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (06) :791-796
[2]  
Albrecht R, 1977, Prog Drug Res, V21, P9
[3]   DNA GYRASE AND THE SUPERCOILING OF DNA [J].
COZZARELLI, NR .
SCIENCE, 1980, 207 (4434) :953-960
[4]   INVESTIGATIONS INTO THE MECHANISM OF ACTION OF THE ANTIBACTERIAL AGENT NORFLOXACIN [J].
CRUMPLIN, GC ;
KENWRIGHT, M ;
HIRST, T .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1984, 13 :9-23
[5]  
CRUMPLIN GC, 1980, TOPICS ANTIBIOTIC CH, V3, P11
[6]   FUNCTIONALIZATION OF SUBSTITUTED 2(1H)-PYRIDONE AND 4(1H)-PYRIDONE .3. THE PREPARATION OF SUBSTITUTED 6-VINYL-1,2-DIHYDRO-2-OXO-PYRIDINECARBOXYLIC AND 1,4-DIHYDRO-4-OXO-3-PYRIDINECARBOXYLIC ACIDS THROUGH THE CHEMISTRY OF PYRIDONE DIANIONS [J].
DEJOHN, D ;
DOMAGALA, JM ;
KALTENBRONN, JS ;
KROLLS, U .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1983, 20 (05) :1295-1302
[7]  
DOMAGALA JM, 1984, 23RD 24TH INT C ANT
[8]   PYRIDONECARBOXYLIC ACIDS AS ANTIBACTERIAL AGENTS .4. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 7-(3-AMINO-1-PYRROLIDINYL)-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID AND ITS ANALOGS [J].
EGAWA, H ;
MIYAMOTO, T ;
MINAMIDA, A ;
NISHIMURA, Y ;
OKADA, H ;
UNO, H ;
MATSUMOTO, J .
JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (12) :1543-1548
[9]   DNA GYRASE AND DNA SUPERCOILING [J].
GELLERT, M ;
MIZUUCHI, K ;
ODEA, MH ;
OHMORI, H ;
TOMIZAWA, J .
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1979, 43 :35-40
[10]   NALIDIXIC-ACID RESISTANCE - 2ND GENETIC CHARACTER INVOLVED IN DNA GYRASE ACTIVITY [J].
GELLERT, M ;
MIZUUCHI, K ;
ODEA, MH ;
ITOH, T ;
TOMIZAWA, JI .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (11) :4772-4776