AKINESIA IN PARKINSONS-DISEASE .2. EFFECTS OF SUBTHRESHOLD REPETITIVE TRANSCRANIAL MOTOR CORTEX STIMULATION

被引：226

作者：

PASCUALLEONE, A

VALLSSOLE, J

BRASILNETO, JP

CAMMAROTA, A

GRAFMAN, J

HALLETT, M

机构：

[1] NINCDS, MED NEUROL BRANCH, HUMAN MOTOR CONTROL SECT, HUMAN CORT PHYSIOL UNIT, BETHESDA, MD 20892 USA

[2] NINCDS, MED NEUROL BRANCH, COGNIT NEUROSCI SECT, BETHESDA, MD 20892 USA

来源：

NEUROLOGY | 1994年 / 44卷 / 05期

关键词：

D O I：

10.1212/WNL.44.5.892

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied the effects of repetitive transcranial stimulation of the motor cortex (rTMS) on choice reaction time (cRT), movement time (MT), and error rate (ER) in a serial reaction-time task in six medicated patients with Parkinson's disease (PD) and 10 age-matched normal controls. In normal subjects, subthreshold 5-Hz rTMS did not significantly change cRT, slightly shortened MT, but increased ER. In the patients, rTMS significantly shortened cRT and MT without affecting ER. These effects did not impair procedural learning. Performance on a grooved pegboard test was improved by rTMS in the same PD patients, especially when they were off medications, but worsened in the normal subjects. Repetitive, subthreshold motor cortex stimulation can improve performance in patients with PD and could be useful therapeutically.

引用

页码：892 / 898

页数：7

共 54 条

[1] PERFORMANCE OF SIMULTANEOUS MOVEMENTS IN PATIENTS WITH PARKINSONS-DISEASE [J].