A HIGH-RESOLUTION LINKAGE MAP OF HUMAN 9Q34.1

被引：27

作者：

HENSKE, EP

OZELIUS, L

GUSELLA, JF

HAINES, JL

KWIATKOWSKI, DJ

机构：

[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DIV EXPTL MED & HEMATOL ONCOL,BOSTON,MA 02115

[2] MASSACHUSETTS GEN HOSP,NEUROGENET LAB,BOSTON,MA 02114

来源：

GENOMICS | 1993年 / 17卷 / 03期

关键词：

D O I：

10.1006/geno.1993.1376

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A map comprising 16 distinct markers with heterozygosities of 0.61-0.92 for a 10-cM region of human 9q34.1 is presented. The map incorporates four genes and has a maximum intermarker interval of 2.1 cM. Markers were analyzed in the Venezuelan reference pedigrees and all were placed uniquely in the map with a minimum likelihood of 676:1. The map should prove useful in analysis of families segregating dystonia and tuberous sclerosis, as the DYT1 and TSC1 loci map within this region. © 1993 Academic Press, Inc.

引用

页码：587 / 591

页数：5

共 18 条

[1]

BUETOW KH, 1991, AM J HUM GENET, V49, P985

[2]

FRYER AE, 1987, LANCET, V1, P659

[3] A GENETIC-LINKAGE MAP OF CHROMOSOME-17 [J].

HAINES, JL ;

OZELIUS, LJ ;

MCFARLANE, H ;

MENON, A ;

TZALL, S ;

MARTINIUK, F ;

HIRSCHHORN, R ;

GUSELLA, JF .

GENOMICS, 1990, 8 (01) :1-6

[4] CHROMLOOK - AN INTERACTIVE PROGRAM FOR ERROR-DETECTION AND MAPPING IN REFERENCE LINKAGE DATA [J].

HAINES, JL .

GENOMICS, 1992, 14 (02) :517-519

[5]

HAINES JL, 1991, AM J HUM GENET, V49, P764

[6] A RADIATION-REDUCED HYBRID CELL-LINE CONTAINING 5 MB/17 CM OF HUMAN DNA FROM 9Q34 [J].

HENSKE, EP ;

OZELIUS, L ;

ANDERSON, MA ;

KWIATKOWSKI, DJ .

GENOMICS, 1992, 13 (03) :841-844

[7]

Johnson P. H., 1992, Human Molecular Genetics, V1, P341, DOI 10.1093/hmg/1.5.341

[8] LINKAGE OF AN IMPORTANT GENE LOCUS FOR TUBEROUS SCLEROSIS TO A CHROMOSOME 16 MARKER FOR POLYCYSTIC KIDNEY-DISEASE [J].

KANDT, RS ;

HAINES, JL ;

SMITH, M ;

NORTHRUP, H ;

GARDNER, RJM ;

SHORT, MP ;

DUMARS, K ;

ROACH, ES ;

STEINGOLD, S ;

WALL, S ;

BLANTON, SH ;

FLODMAN, P ;

KWIATKOWSKI, DJ ;

JEWELL, A ;

WEBER, JL ;

ROSES, AD ;

PERICAKVANCE, MA .

NATURE GENETICS, 1992, 2 (01) :37-41

[9] CONSTRUCTION OF A GT POLYMORPHISM MAP OF HUMAN 9Q [J].

KWIATKOWSKI, DJ ;

HENSKE, EP ;

WEIMER, K ;

OZELIUS, L ;

GUSELLA, JF ;

HAINES, J .

GENOMICS, 1992, 12 (02) :229-240

[10]

KWIATKOWSKI DJ, 1991, AM J HUM GENET, V49, P366

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