UNUSUAL SOLUBILITY BEHAVIOR OF CYCLOSPORINE-A IN AQUEOUS-MEDIA

被引：107

作者：

ISMAILOS, G

REPPAS, C

DRESSMAN, JB

MACHERAS, P

机构：

[1] UNIV ATHENS,DEPT PHARM,104 SOLONOS ST,GR-10680 ATHENS,GREECE

[2] UNIV MICHIGAN,COLL PHARM,ANN ARBOR,MI 48109

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1991年 / 43卷 / 04期

关键词：

D O I：

10.1111/j.2042-7158.1991.tb06688.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The solubility of cyclosporin A was determined in water and in Sorensen buffers at pH 1.2 and 6.6 at temperatures ranging from 5 to 37-degrees-C. No differences in solubility behaviour were observed among the three aqeous media. Solubility was found to be inversely proportional to the temperature in each medium, indicating that the heat of solution was exothermic in each case.

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页码：287 / 289

页数：3

相关论文

共 14 条

[1]

CONIO G, 1973, J BIOL CHEM, V248, P5448

[2] SOLID SURFACTANT SOLUTIONS OF ACTIVE INGREDIENTS IN SUGAR ESTERS [J].

HAHN, L ;

SUCKER, H .

PHARMACEUTICAL RESEARCH, 1989, 6 (11) :958-960

[3]

Humphrey M. J., 1986, DELIVERY SYSTEMS PEP, P139

[4] CYCLOSPORINE - MEASUREMENT OF FRACTION UNBOUND IN PLASMA [J].

LEGG, B ;

ROWLAND, M .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1987, 39 (08) :599-603

[5] PEPTIDE CONFORMATIONS .31. THE CONFORMATION OF CYCLOSPORIN-A IN THE CRYSTAL AND IN SOLUTION [J].

LOOSLI, HR ;

KESSLER, H ;

OSCHKINAT, H ;

WEBER, HP ;

PETCHER, TJ ;

WIDMER, A .

HELVETICA CHIMICA ACTA, 1985, 68 (03) :682-704

[6] EFFECT OF TEMPERATURE AND FAT-CONTENT ON THE SOLUBILITY OF HYDROCHLOROTHIAZIDE AND CHLOROTHIAZIDE IN MILK [J].

MACHERAS, PE ;

KOUPPARIS, MA ;

ANTIMISIARIS, SG .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1989, 78 (11) :933-936

[7] DRUG-BINDING AND SOLUBILITY IN MILK [J].

MACHERAS, PE ;

KOUPPARIS, MA ;

ANTIMISIARIS, SG .

PHARMACEUTICAL RESEARCH, 1990, 7 (05) :537-541

[8] EFFECTS OF TEMPERATURE ON DISSOLUTION AND PRECIPITATION OF PROTEINS AND POLYAMINO ACIDS [J].

MACRITCHIE, F .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1973, 45 (02) :235-241

[9]

MARTIN AN, 1970, PHYSICAL PHARM, P125

[10] CLINICAL PHARMACOKINETICS OF CYCLOSPORINE [J].

PTACHCINSKI, RJ ;

VENKATARAMANAN, R ;

BURCKART, GJ .

CLINICAL PHARMACOKINETICS, 1986, 11 (02) :107-132