THE EFFECT OF SOMATOSTATIN ON STRIATAL CATECHOLAMINES

被引：60

作者：

BEAL, MF ^{[1
]}

MARTIN, JB ^{[1
]}

机构：

[1] MASSACHUSETTS GEN HOSP, DEPT NEUROL, NEUROL RES LAB, BOSTON, MA 02114 USA

来源：

NEUROSCIENCE LETTERS | 1984年 / 44卷 / 03期

关键词：

D O I：

10.1016/0304-3940(84)90034-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Somatostatin and several analogs were injected into rat striatum and their effects on dopamine [DA], serotonin [5-hydroxytryptamine, 5-HT] and their metabolites were examined at 1 h. Somatostatin induced a dose-dependent increase in DA turnover in the ipsilateral striatum accompanied by a reduction in turnover on the contralateral side. There was no effect on 5-HT turnover. Long-acting somatostatin analogs (D-Trp-8-somatostatin, SMS-201-995) had similar effects. Somatostatin is inovlved in local regulation of striatal dopaminergic transmission and that it plays a role in regulation of DA release in the contralateral striatum.

引用

页码：271 / 276

页数：6

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