EFFICACY OF ORAL POLIOVIRUS VACCINE IN RURAL COMMUNITIES OF NORTH-ARCOT DISTRICT, INDIA

Balraj V (Department of Virology, Christian Medical College Hospital, Vellore, Tamilnadu, 632 004, India), John T J, Thomas M and Mukundan S. Efficacy of oral poliovirus vaccine in rural communities of North Arcot District, India. InternationalJournal of Epidemiology 1990; 19: 711-714.The protective efficacy of three doses of oral poliovirus vaccine (OPV) was measured in children under five in the rural blocks of North Arcot District. In 1988, a sample survey of 7% of the total population of the district (population five million) was conducted to determine the immunization coverage with OPV and the incidence of paralytic poliomyelitis in under-fivesin the previous 12 months, (n = 42 045). For every case of poliomyelitis, all children matched for exact age in months resident within the same block were taken as controls. Some 67 children had poliomyelitis (prevalence of lameness 1.59/1000, estimated annual incidence 2.57/1000 under-fives). Among cases and controls 24 and 42%, respectively, had received three doses of OPV, while 44 and 33% had received none. In a case-control analysis, the vaccine efficacy (VE) was 62% for all under-fives; for the 12-23 months age group it was 71.4%. For a vaccine with the potential of near 100% VE, this is disappointingly low. Obviously, not only the immunization coverage level, but also the VE should be enhanced if poliomyelitis is to be controlled in India. This may be achieved by a five-dose OPV schedule, annual OPV immunization campaigns in addition to the routine three-dose schedule or by using inactivated poliovirus vaccine of enhanced potency. © 1990 International Epidemiological Association.