A COMMON MECHANISM OF TRANSCRIPTIONAL ACTIVATION BY THE 3 POSITIVE REGULATORS, VIRG, PHOB, AND OMPR

被引：23

作者：

AOYAMA, T

OKA, A

机构：

[1] Laboratory of Molecular Biology, Institute for Chemical Research, Kyoto University, Uji-shi, 611, Kyoto-fu

来源：

FEBS LETTERS | 1990年 / 263卷 / 01期

关键词：

Cis-acting element; DNA-binding protein; Phased sequence; Transcriptional activation; Two-component regulatory system;

D O I：

10.1016/0014-5793(90)80691-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

VirG, PhoB, and OmpR are positive regulators of the virulence, phosphate, and osmolarity regulons, respectively. Their target genes are attended with one or more significant blocks of similar 6-bp sequences in their regulatory regions. The distance between the block(s) and transcriptional start site varies with the target genes, but the blocks are located in a similar manner phase-specific to the promoter sequences. On the basis of these facts, we offer a novel model of transcriptional activation common to these regulators. © 1990.

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页码：1 / 4

页数：4

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