OVERPRODUCTION OF A BIFUNCTIONAL THYMIDYLATE SYNTHETASE-DIHYDROFOLATE REDUCTASE AND DNA AMPLIFICATION IN METHOTREXATE-RESISTANT LEISHMANIA-TROPICA

被引:217
作者
CODERRE, JA
BEVERLEY, SM
SCHIMKE, RT
SANTI, DV
机构
[1] UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,DEPT PHARMACEUT CHEM,SAN FRANCISCO,CA 94143
[3] STANFORD UNIV,DEPT BIOL SCI,STANFORD,CA 94305
来源
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES | 1983年 / 80卷 / 08期
关键词
D O I
10.1073/pnas.80.8.2132
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:2132 / 2136
页数:5
相关论文
共 28 条
[1]   PURIFICATION AND PROPERTIES OF ESCHERICHIA-COLI DIHYDROFOLATE-REDUCTASE [J].
BACCANARI, D ;
PHILLIPS, A ;
SMITH, S ;
SINSKI, D ;
BURCHALL, J .
BIOCHEMISTRY, 1975, 14 (24) :5267-5273
[2]  
BLAKLEY RL, 1969, BIOCH FOLIC ACID REL, P143
[3]   GENE AMPLIFICATION IN METHOTREXATE-RESISTANT MOUSE CELLS .2. REARRANGEMENT AND AMPLIFICATION OF NON-DIHYDROFOLATE REDUCTASE GENE-SEQUENCES ACCOMPANY CHROMOSOMAL CHANGES [J].
BOSTOCK, CJ ;
TYLERSMITH, C .
JOURNAL OF MOLECULAR BIOLOGY, 1981, 153 (02) :219-236
[4]  
BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[5]   RELATIONSHIP OF AMPLIFIED DIHYDROFOLATE-REDUCTASE GENES TO DOUBLE MINUTE CHROMOSOMES IN UNSTABLY RESISTANT MOUSE FIBROBLAST CELL-LINES [J].
BROWN, PC ;
BEVERLEY, SM ;
SCHIMKE, RT .
MOLECULAR AND CELLULAR BIOLOGY, 1981, 1 (12) :1077-1083
[6]  
Browning C. H., 1954, Annals of the New York Academy of Sciences, V59, P198, DOI 10.1111/j.1749-6632.1954.tb45932.x
[7]   PHENOTYPIC EXPRESSION IN ESCHERICHIA-COLI OF A DNA-SEQUENCE CODING FOR MOUSE DIHYDROFOLATE-REDUCTASE [J].
CHANG, ACY ;
NUNBERG, JH ;
KAUFMAN, RJ ;
ERLICH, HA ;
SCHIMKE, RT ;
COHEN, SN .
NATURE, 1978, 275 (5681) :617-624
[8]  
CROUSE GF, 1982, J BIOL CHEM, V257, P7887
[9]  
Davis RW, 1980, ADV BACTERIAL GENETI
[10]  
EHRLICH P, 1908, EXPT RES SPECIFIC TH, P81