DISTRIBUTION OF THE MAMMALIAN STAT GENE FAMILY IN MOUSE CHROMOSOMES

被引：173

作者：

COPELAND, NG

GILBERT, DJ

SCHINDLER, C

ZHONG, Z

WEN, Z

DARNELL, JE

MUI, ALF

MIYAJIMA, A

QUELLE, FW

IHLE, JN

JENKINS, NA

机构：

[1] ROCKEFELLER UNIV, MOLEC CELL BIOL LAB, NEW YORK, NY 10021 USA

[2] DNAX RES INST MOLEC & CELLULAR BIOL INC, DEPT CELL BIOL, PALO ALTO, CA 94304 USA

[3] ST JUDE CHILDRENS RES HOSP, DEPT BIOCHEM, MEMPHIS, TN 38105 USA

来源：

GENOMICS | 1995年 / 29卷 / 01期

关键词：

D O I：

10.1006/geno.1995.1235

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Studies of transcriptional activation by interferons and a variety of cytokines have led to the identification of a family of proteins that serve as signal transducers and activators of transcription, Stats. Here, we report that the seven mouse Stat loci map in three clusters, with each cluster located on a different mouse autosome. The data suggest that the family has arisen via a tandem duplication of the ancestral locus, followed by dispersion of the linked loci to different mouse chromosomes. (C) 1995 Academic Press, Inc.

引用

页码：225 / 228

页数：4

共 28 条

[1]

AKIRA S, 1994, CELL, V77, P68

[2] INTERLEUKIN-3 SIGNALS THROUGH MULTIPLE ISOFORMS OF STAT5 [J].