Bio-repository of DNA in stroke: a study protocol of three ancestral populations

被引：9

作者：

Cotlarciuc, Ioana ^{[1
]}

Khan, Muhammad Saleem ^{[1
]}

Maheshwari, Ankita ^{[2
]}

Yadav, Sunaina ^{[1
]}

Khan, Fahmi Yousif ^{[3
]}

Al-Hail, H. ^{[3
]}

de Silva, Ranil ^{[4
]}

Gorthi, S. P. ^{[5
]}

Gupta, Salil ^{[6
]}

Sharma, Shri Ram ^{[7
]}

Sylaja, P. N. ^{[8
]}

Prasad, Kameshwar ^{[2
]}

Sharma, Pankaj ^{[1
]}

机构：

[1] Imperial Coll London, ICCRU, London, England

[2] All India Inst Med Sci, Dept Neurol, Delhi, India

[3] Hamad Med Corp, Doha, Qatar

[4] Univ Sri Jayewardenepura, Dept Anat, Nugegoda, Sri Lanka

[5] Army Hosp, Delhi, India

[6] Armed Forces Med Coll, Pune, Maharashtra, India

[7] North Eastern Indira Gandhi Reg Inst Hlth & Med S, Shillong, Meghalaya, India

[8] Sree Chitra Tirunal Inst Med Sci & Technol, Comprehens Stroke Care Programme, Dept Neurol, Trivandrum, Kerala, India

来源：

JRSM CARDIOVASCULAR DISEASE | 2012年 / 1卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1258/cvd.2012.012019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Stroke is a leading cause of death and disability in the world. Identifying the genes underlying stroke risk may help us to improve our understanding of the mechanisms that cause stroke and also identify novel therapeutic targets. To have sufficient power to disentangle the genetic component of stroke, large-scale highly phenotyped DNA repositories are necessary. The BRAINS (Bio-repository of DNA in stroke) study aims to recruit subjects with all subtypes of stroke aswell as controls from UK, India, Sri Lanka and Qatar. BRAINS-UK will include 1500 stroke patients of European ancestry as well as British South Asians. BRAINSSouth Asia aims to recruit 3000 stroke subjects and 3000 controls from across India and Sri Lanka. BRAINS-Middle East aims to enrol 1500 stroke patients from Qatar. The controls for BRAINS-Middle East will be recruited from a population-based Qatari Biobank. With the addition of new recruitment centres in India and Qatar, we present an updated version of the BRAINS study protocol. This is the first international DNA biobank for stroke patients and controls from the Middle East. By investigating the influence of genetic factors on stroke risk in European, South Asian and Middle Eastern populations, BRAINS has the potential to improve our understanding of genetic differences between these groups and may lead to new population-specific therapeutic targets.

引用

页数：8

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