CD4+8- HELP PREVENTS RAPID DELETION OF CD8+ CELLS AFTER A TRANSIENT-RESPONSE TO ANTIGEN

被引：81

作者：

KIRBERG, J

BRUNO, L

VONBOEHMER, H

机构：

[1] Basel Institute for Immunology, Basel

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1993年 / 23卷 / 08期

关键词：

TOLERANCE; H-Y ANTIGEN; TRANSGENIC MICE; CLONAL DELETION; T-CELL HELP;

D O I：

10.1002/eji.1830230835

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have followed the fate of mature CD8+ T cells with a male-specific transgenic T cell receptor after antigenic stimulation with hemopoietic cells in the absence or presence of help. Our data show that mature CD8+ T cells can be deleted after a 3-week period of transient activation and that help, e.g. in the form of interleukin-2, can considerably delay the deletion. These experiments have implications for the design of protocols aiming at the establishment of specific immunological tolerance in T cells.

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收藏

页码：1963 / 1967

页数：5

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