ANOREXIA FOLLOWING THE SYSTEMIC INJECTION OF AMYLIN

被引：66

作者：

CHANCE, WT ^{[1
]}

BALASUBRAMANIAM, A ^{[1
]}

STALLION, A ^{[1
]}

FISCHER, JE ^{[1
]}

机构：

[1] VET AFFAIRS MED CTR,CINCINNATI,OH

来源：

BRAIN RESEARCH | 1993年 / 607卷 / 1-2期

关键词：

ANOREXIA; DIABETES-ASSOCIATED PEPTIDE; CORPUS STRIATUM; HYPOTHALAMUS; 3-METHOXYTYRAMINE; DOPAMINE; SEROTONIN; GLUCOSE; CALCITONIN GENE-RELATED PEPTIDE;

D O I：

10.1016/0006-8993(93)91505-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The intravenous injection of 100 mug/kg of rat amylin reduced food intake in schedule-fed rats for 1 h of an 8 h measurement period. Associated with this brief anorexia was a hyperglycemic response, observed 30 min after a subsequent amylin administration. Determination of neurochemical alterations revealed increased concentration of serotonin in the hypothalamus and decreased level of the dopamine metabolite, 3-methoxytyramine, in the corpus striatum. Since similar neurochemical alterations were observed following the systemic injection of glucose, both the neurochemical changes and anorexia following intravenous amylin treatment may be secondary to hyperglycemia.

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收藏

页码：185 / 188

页数：4

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