ESTROGEN RAPIDLY POTENTIATES AMPHETAMINE-INDUCED STRIATAL DOPAMINE RELEASE AND ROTATIONAL BEHAVIOR DURING MICRODIALYSIS

被引：252

作者：

BECKER, JB ^{[1
]}

机构：

[1] UNIV MICHIGAN,NEUROSCI PROGRAM,ANN ARBOR,MI 48104

来源：

NEUROSCIENCE LETTERS | 1990年 / 118卷 / 02期

关键词：

Amphetamine; Dopamine release; Estrogen; Microdialysis; Rotational behavior; Striatum;

D O I：

10.1016/0304-3940(90)90618-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ovariectomy (OVX) of female rats results in a decreased behavioral response to stimulation of the mesostriatal dopamine (DA) system and decreased striatal DA release in vitro. Estrogen replacement restores both behavioral and neurochemical responsiveness. In this report, microdialysis in freely moving rats is used to simultaneously study the behavioral and neurochemical effects of systemic estradiol. OVX rats received a unilateral 6-hydroxy-dopamine lesion of the substantia nigra and then underwent microdialysis of the intact striatum. Thirty min after a single injection of 5 μg estradiol benzoate, amphetamine-induced rotational behavior and striatal DA release are both potentiated, relative to the response of oil-treated control animals. © 1990.

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页码：169 / 171

页数：3

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