The human genome: Organization and evolutionary history

被引：298

作者：

Bernardi, G

机构：

[1] Lab. de Genet. Moléculaire, Institut Jacques Monod, 75005 Paris

来源：

ANNUAL REVIEW OF GENETICS | 1995年 / 29卷

关键词：

chromosomes; evolution; genome; isochores; vertebrates;

D O I：

10.1146/annurev.ge.29.120195.002305

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

This review outlines briefly the compositional properties of the vertebrate genome, namely its isochore organization, the compositional patterns of DNA molecules and of coding sequences, the compositional correlations between coding and noncoding sequences, and the relationships between isochores and chromosomal bands. It then deals with the fundamental properties of the vertebrate genome, namely the distribution of genes and its associated functional features. Finally, it considers how the structural and functional organization of the human genome (and of the genomes of warm-blooded vertebrates in general) arose in evolution.

引用

页码：445 / 476

页数：32

共 125 条

[1] CPG ISLANDS, GENES AND ISOCHORES IN THE GENOMES OF VERTEBRATES [J].