DISSECTING THE COMPLEXITY OF THE NERVOUS-SYSTEM BY ENHANCER DETECTION

被引：30

作者：

BELLEN, HJ

WILSON, C

GEHRING, WJ

机构：

[1] BAYLOR UNIV,DEPT CELL BIOL,HOUSTON,TX 77030

[2] UNIV BASEL,BIOCTR,DEPT CELL BIOL,CH-4056 BASEL,SWITZERLAND

来源：

BIOESSAYS | 1990年 / 12卷 / 05期

关键词：

D O I：

10.1002/bies.950120502

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Enhancer detectors are DNA constructs which, when introduced into a eukaryotic genome, respond to nearby genomic transcriptional regulatory elements by means of a reporter gene, revealing the expression pattern of genes in their vicinity. Recent experiments in Drosophila suggest that enhancer detection is a powerful method to identify genes that are expressed in the nervous system. Since enhancer detectors allow a rapid molecular and genetic characterization of genes in their vicinity, the method will greatly facilitate the study of neural development and behavior. Copyright © 1990 Cambridge University Press

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页码：199 / 204

页数：6

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