CELLULAR PEPTIDE COMPOSITION GOVERNED BY MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I MOLECULES

被引：414

作者：

FALK, K ^{[1
]}

ROTZSCHKE, O ^{[1
]}

RAMMENSEE, HG ^{[1
]}

机构：

[1] MAX PLANCK INST BIOL,IMMUNOGENET ABT,CORRENSSTR 42,W-7400 TUBINGEN,GERMANY

来源：

NATURE | 1990年 / 348卷 / 6298期

关键词：

D O I：

10.1038/348248a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

MAJOR histocompatibility complex (MHC) class I molecules present peptides derived from cellular proteins to cytotoxic T lymphocytes (CTLs)1-5, which check these peptides for abnormal features. How such peptides arise in the cell is not known. Here we show that the MHC molecules themselves are substantially involved in determining which peptides occur intracellularly: normal mouse spleen cells identical at all genes but MHC class I express different patterns of peptides derived from cellular non-MHC proteins. We suggest several models to explain this influence of MHC class I molecules on cellular peptide composition. © 1990 Nature Publishing Group.

引用

页码：248 / 251

页数：4

共 18 条

[1]

ALLEN PM, 1986, I PASTEUR IMMUN D, V137, P182

[2]

BEVAN MJ, 1975, NATURE, V256, P417

[3] STRUCTURE OF THE HUMAN CLASS-I HISTOCOMPATIBILITY ANTIGEN, HLA-A2 [J].

BJORKMAN, PJ ;

SAPER, MA ;

SAMRAOUI, B ;

BENNETT, WS ;

STROMINGER, JL ;

WILEY, DC .

NATURE, 1987, 329 (6139) :506-512

[4] T-CELL-RECOGNIZED ANTIGENIC PEPTIDES DERIVED FROM THE CELLULAR GENOME ARE NOT PROTEIN-DEGRADATION PRODUCTS BUT CAN BE GENERATED DIRECTLY BY TRANSCRIPTION AND TRANSLATION OF SHORT SUBGENIC REGIONS - A HYPOTHESIS [J].

BOON, T ;

VANPEL, A .

IMMUNOGENETICS, 1989, 29 (02) :75-79

[5]

DONERMEYER DL, 1989, J IMMUNOL, V142, P1063

[6]

GRAFF RJ, 1978, ORIGINS INBRED MICE, P371

[7] H-2 HAPLOTYPES, GENES AND ANTIGENS - 2ND LISTING .2. THE H-2-COMPLEX [J].

KLEIN, J ;

FIGUEROA, F ;

DAVID, CS .

IMMUNOGENETICS, 1983, 17 (06) :553-596

[8] INTRACELLULAR TRAFFIC AND ANTIGEN PROCESSING [J].

LONG, EO .

IMMUNOLOGY TODAY, 1989, 10 (07) :232-234

[9] BREFELDIN-A IMPLICATES EGRESS FROM ENDOPLASMIC-RETICULUM IN CLASS-I RESTRICTED ANTIGEN PRESENTATION [J].

NUCHTERN, JG ;

BONIFACINO, JS ;

BIDDISON, WE ;

KLAUSNER, RD .

NATURE, 1989, 339 (6221) :223-226

[10] PROTEIN-SPECIFIC CYTO-TOXIC LYMPHOCYTE-T - RECOGNITION OF TRANSFECTANTS EXPRESSING INTRACELLULAR, MEMBRANE-ASSOCIATED OR SECRETED FORMS OF BETA-GALACTOSIDASE [J].

RAMMENSEE, HG ;

SCHILD, H ;

THEOPOLD, U .

IMMUNOGENETICS, 1989, 30 (04) :296-302

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