PREVENTION OF T-CELL ANERGY BY SIGNALING THROUGH THE GAMMA(C) CHAIN OF THE IL-2 RECEPTOR

被引：318

作者：

BOUSSIOTIS, VA

BARBER, DL

NAKARAI, T

FREEMAN, GJ

GRIBBEN, JG

BERNSTEIN, GM

DANDREA, AD

RITZ, J

NADLER, LM

机构：

[1] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV PEDIAT ONCOL,BOSTON,MA 02115

[3] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV CELLULAR & MOLEC BIOL,BOSTON,MA 02115

[4] HARVARD UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02115

来源：

SCIENCE | 1994年 / 266卷 / 5187期

关键词：

D O I：

10.1126/science.7973657

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

When stimulated through their antigen receptor without requisite costimulation, T cells enter a state of antigen-specific unresponsiveness, termed anergy. In this study, signaling through the common gamma chain of the interleukin-2 (IL-2), IL-4, and IL-7 receptors in the presence of antigen was found to be sufficient to prevent the induction of anergy. After culture with IL-2, IL-4, or IL-7, Jak3 kinase was tyrosine-phosphorylated, which correlated with the prevention of anergy. Therefore, a signal through the common gamma chain may regulate the decision of T cells to either clonally expand or enter a state of anergy.

引用

页码：1039 / 1042

页数：4

共 51 条

[1] ERYTHROPOIETIN AND INTERLEUKIN-2 ACTIVATE DISTINCT JAK KINASE FAMILY MEMBERS [J].