CONFORMATION OF [1-C-13,N-15]ACETYL-L-CARNITINE - ROTATIONAL-ECHO, DOUBLE-RESONANCE NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY

被引：48

作者：

ANDERSON, RC

GULLION, T

JOERS, JM

SHAPIRO, M

VILLHAUER, EB

WEBER, HP

机构：

[1] FLORIDA STATE UNIV,DEPT CHEM,TALLAHASSEE,FL 32306

[2] SANDOZ INC,RES INST,DEPT CENT TECHNOL,E HANOVER,NJ 07936

[3] SANDOZ INC,RES INST,DEPT METAB DIS,E HANOVER,NJ 07936

[4] SANDOZ INC,RES INST,DEPT PRECLIN RES,E HANOVER,NJ 07936

[5] SANDOZ LTD,DRUG DESIGN GRP,CH-4002 BASEL,SWITZERLAND

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1995年 / 117卷 / 42期

关键词：

D O I：

10.1021/ja00147a016

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The conformation of [1-C-13,N-15]acetyl-L-carnitine is studied by rotational-echo, double-resonance (REDOR) NMR experiments. The REDOR results show that acetyl-L-carnitine adopts an extended molecular conformation in the solid state for both crystalline and lyophilized samples. These findings are in contrast to various X-ray-determined structures of racemic acetylcarnitine showing folded conformations.

引用

页码：10546 / 10550

页数：5

共 25 条

[1]

ANDERSON R, IN PRESS ACTA CRYS A

[2]

BREMER J, 1962, J BIOL CHEM, V237, P2228

[3] REEXAMINATION OF THE H-1-NMR ASSIGNMENTS AND SOLUTION CONFORMATIONS OF L-CARNITINE AND O-ACETYL-L-CARNITINE USING C-2 STEREOSPECIFICALLY LABELED MONODEUTERATED ISOMERS [J].