PHARMACOLOGICAL PROFILE OF A NOVEL CARBACYCLIN DERIVATIVE WITH HIGH METABOLIC STABILITY AND ORAL ACTIVITY IN THE RAT

被引：81

作者：

STURZEBECHER, S ^{[1
]}

HABEREY, M ^{[1
]}

MULLER, B ^{[1
]}

SCHILLINGER, E ^{[1
]}

SCHRODER, G ^{[1
]}

SKUBALLA, W ^{[1
]}

STOCK, G ^{[1
]}

VORBRUGGEN, H ^{[1
]}

WITT, W ^{[1
]}

机构：

[1] SCHERING AG,RES LABS,BERGKAMEN,FED REP GER

来源：

PROSTAGLANDINS | 1986年 / 31卷 / 01期

关键词：

D O I：

10.1016/0090-6980(86)90228-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：95 / 109

页数：15

共 21 条

[1]

ADDONIZIO VP, 9TH P S IL EUR C CAR

[2] PROSTAGLANDINS - ENZYMATIC ANALYSIS [J].

ANGGARD, E ;

MATSCHINSKY, FM ;

SAMUELSSON, B .

SCIENCE, 1969, 163 (3866) :479-+

[3]

HENRIKSSON P, 1985, BRIT HEART J, V53, P173

[4]

HIGENBOTTAM T, 1984, LANCET, V1, P1046

[5]

HILDEBRAND MG, UNPUB

[6] HEMODYNAMIC-EFFECTS OF ILOPROST, A PROSTACYCLIN ANALOG [J].

KAUKINEN, S ;

YLITALO, P ;

PESSI, T ;

VAPAATALO, H .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1984, 36 (04) :464-469

[7] PHARMACOKINETICS AND BIOTRANSFORMATION OF THE PROSTACYCLIN ANALOG, ZK 36 374, IN THE MONKEY (MACACA-FASCICULARIS) [J].

KRAUSE, W ;

SCHUBERT, M ;

TOTZEK, M .

PROSTAGLANDINS LEUKOTRIENES AND MEDICINE, 1983, 11 (03) :325-338

[8]

KRAUSE W, 1984, DRUG METAB DISPOS, V12, P645

[9]

LOGE O, COMMUNICATION

[10] ENZYME ISOLATED FROM ARTERIES TRANSFORMS PROSTAGLANDIN ENDOPEROXIDES TO AN UNSTABLE SUBSTANCE THAT INHIBITS PLATELET-AGGREGATION [J].

MONCADA, S ;

GRYGLEWSKI, R ;

BUNTING, S ;

VANE, JR .

NATURE, 1976, 263 (5579) :663-665

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