ALPHA-9 - AN ACETYLCHOLINE-RECEPTOR WITH NOVEL PHARMACOLOGICAL PROPERTIES EXPRESSED IN RAT COCHLEAR HAIR-CELLS

被引：751

作者：

ELGOYHEN, AB ^{[1
]}

JOHNSON, DS ^{[1
]}

BOULTER, J ^{[1
]}

VETTER, DE ^{[1
]}

HEINEMANN, S ^{[1
]}

机构：

[1] SALK INST BIOL STUDIES, LA JOLLA, CA 92037 USA

来源：

CELL | 1994年 / 79卷 / 04期

关键词：

D O I：

10.1016/0092-8674(94)90555-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the isolation and funational characterization of a member of the nicotinic acetylcholine receptor subunit gene family, alpha 9. Xenopus oocytes injected with alpha 9 cRNA express a homomeric receptor-channel complex that is activated by acetylcholine. The alpha 9 receptor displays an unusual mixed nicotinic-muscarinic pharmacological profile. The unique properties of the alpha 9 receptor-channel complex closely match those described for the cholinergic receptor present in vertebrate cochlear hair cells. In situ hybridization studies reveal a restricted pattern of alpha 9 gene expression that includes the outer hair cells of the rat cochlea. Our results suggest that the alpha 9 receptor is involved in the cholinergic efferent innervation of cochlear hair cells and thus may modulate the encoding of auditory stimuli.

引用

页码：705 / 715

页数：11

共 50 条

[1] ELECTROPHYSIOLOGY OF A CHICK NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTOR EXPRESSED IN XENOPUS OOCYTES AFTER CDNA INJECTION [J].