P75 AND TRK - A 2-RECEPTOR SYSTEM

被引：746

作者：

CHAO, MV

HEMPSTEAD, BL

机构：

来源：

TRENDS IN NEUROSCIENCES | 1995年 / 18卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0166-2236(95)93922-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neurotrophin family of survival factors is distinguished by a unique receptor-signaling system that is composed of two transmembrane receptor proteins. Nerve growth factor (NGF), brain-derived neurotrophic factor, neurotrophin-3 (NT-3) and NF-4/5 share similar protein structures and biological functions and interact with two different types of cell-surface proteins, the Trk family of receptor tyrosine kinases, and the p75, or low-affinity neurotrophin receptor. An important question is whether a dual receptor system is necessary for neurotrophin action. Evidence indicates that co-expression of the two genes for the p75 receptor and the Trk NGF receptor can potentially lead to greater responsiveness to NGF, and suggests additional levels of regulation for the family of neurotrophin factors.

引用

页码：321 / 326

页数：6

共 61 条

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