BRAIN-STEM ACTIVATION IN SPONTANEOUS HUMAN MIGRAINE ATTACKS

被引：1025

作者：

WEILLER, C

MAY, A

LIMMROTH, V

JUPTNER, M

KAUBE, H

VONSCHAYCK, R

COENEN, HH

DIENER, HC

机构：

[1] UNIV ESSEN GESAMTHSCH,DEPT NEUROL,D-45122 ESSEN,GERMANY

[2] UNIV ESSEN GESAMTHSCH,DEPT NUCL MED,RADIOPHARM SECT,D-45122 ESSEN,GERMANY

来源：

NATURE MEDICINE | 1995年 / 1卷 / 07期

关键词：

D O I：

10.1038/nm0795-658

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evidence from animal experiments shows that the brain stem is involved in the pathophysiology of migraine. To investigate human migraine, we used positron emission tomography to examine the changes in regional cerebral blood flow as an index of neuronal activity in the human brain during spontaneous migraine attacks. During the attacks, increased blood flow was found in the cerebral hemispheres in cingulate, auditory and visual association cortices and in the brain stem. However, only the brain stem activation persisted after the injection of sumatriptan had induced complete relief from headache and phono- and photophobia These findings support the idea that the pathogenesis of migraine is related to an imbalance in activity between brain stem nuclei regulating antinociception and vascular control.

引用

页码：658 / 660

页数：3

共 28 条

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