REGULATION OF INTERLEUKIN-5 PRODUCTION BY PERIPHERAL-BLOOD MONONUCLEAR-CELLS FROM ATOPIC PATIENTS WITH FK506, CYCLOSPORINE-A AND GLUCOCORTICOID

被引：47

作者：

MORI, A

SUKO, M

NISHIZAKI, Y

KAMINUMA, O

MATSUZAKI, G

ITO, K

ETOH, T

NAKAGAWA, H

TSURUOKA, N

OKUDAIRA, H

机构：

[1] UNIV TOKYO, FAC MED, DEPT MED & PHYS THERAPY, TOKYO 113, JAPAN

[2] UNIV TOKYO, FAC MED, DEPT DERMATOL, TOKYO 113, JAPAN

[3] SUNTORY INST BIOMED RES, MISHIMA, OSAKA, JAPAN

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1994年 / 104卷

关键词：

INTERLEUKIN-5; BRONCHIAL ASTHMA; ATOPIC DERMATITIS; IMMUNOSUPPRESSIVE DRUGS; CYCLOSPORINE A; FK506; GLUCOCORTICOID; NUCLEAR OF ACTIVATED T CELLS; ACTIVATION PROTEIN 1;

D O I：

10.1159/000236745

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Upon stimulation with phorbol ester and ionomycin, peripheral blood mononuclear cells (PBMC) of atopic patients with moderate eosinophilia produced significantly higher amounts of IL-5 compared to that of normal subjects. This finding renders further support to the notion that T cell-eosinophilic inflammation plays a central role in allergic disorders. IL-5 induction in vitro was completely inhibited by immunosuppressant FK506, cyclosporin A and dexamethasone. FK506 applied in vivo effectively suppressed clinical symptoms of atopic dermatitis and IL-5 production of PBMC. FK506 and cyclosporin A may become a better therapeutic modality against allergic diseases.

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页码：32 / 35

页数：4

相关论文

共 22 条

[1] IDENTIFICATION OF ACTIVATED LYMPHOCYTES-T AND EOSINOPHILS IN BRONCHIAL BIOPSIES IN STABLE ATOPIC ASTHMA [J].

AZZAWI, M ;

BRADLEY, B ;

JEFFERY, PK ;

FREW, AJ ;

WARDLAW, AJ ;

KNOWLES, G ;

ASSOUFI, B ;

COLLINS, JV ;

DURHAM, S ;

KAY, AB .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 142 (06) :1407-1413

[2] IMMEDIATE AND LATE BRONCHIAL OBSTRUCTIVE REACTIONS TO INHALATION OF HOUSE DUST AND PROTECTIVE EFFECTS OF DISODIUM CROMOGLYCATE AND PREDNISOLONE [J].

BOOIJNOORD, H ;

ORIE, NGM ;

DEVRIES, K .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1971, 48 (06) :344-+

[3] MOLECULAR-CLONING, NUCLEOTIDE-SEQUENCE, AND EXPRESSION OF THE GENE ENCODING HUMAN EOSINOPHIL DIFFERENTIATION FACTOR (INTERLEUKIN-5) [J].

CAMPBELL, HD ;

TUCKER, WQJ ;

HORT, Y ;

MARTINSON, ME ;

MAYO, G ;

CLUTTERBUCK, EJ ;

SANDERSON, CJ ;

YOUNG, IG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (19) :6629-6633

[4] THE EFFECT OF CORTISONE ON BRONCHIAL ASTHMA AND HAY FEVER OCCURRING IN SUBJECTS SENSITIVE TO RAGWEED POLLEN [J].

CARRYER, HM ;

KOELSCHE, GA ;

PRICKMAN, LE ;

MAYTUM, CK ;

LAKE, CF ;

WILLIAMS, HL .

JOURNAL OF ALLERGY, 1950, 21 (04) :282-287

[5]

DEMONCHY JGR, 1985, AM REV RESPIR DIS, V131, P373

[6] BRONCHIAL RESPONSIVENESS TO MITE ALLERGEN IN ATOPIC-DERMATITIS WITHOUT ASTHMA [J].

DOHI, M ;

OKUDAIRA, H ;

SUGIYAMA, H ;

TSURUMACHI, K ;

SUKO, M ;

NAKAGAWA, T ;

MORITA, Y ;

ITO, K ;

NAKAYAMA, H ;

MIYAMOTO, T .

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1990, 92 (02) :138-142

[7] CHARACTERIZATION OF ANTIGEN RECEPTOR RESPONSE ELEMENTS WITHIN THE INTERLEUKIN-2 ENHANCER [J].

DURAND, DB ;

SHAW, JP ;

BUSH, MR ;

REPLOGLE, RE ;

BELAGAJE, R ;

CRABTREE, GR .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (04) :1715-1724

[8] EOSINOPHILS, BRONCHIAL HYPERREACTIVITY AND LATE-PHASE ASTHMATIC REACTIONS [J].

DURHAM, SR ;

KAY, AB .

CLINICAL ALLERGY, 1985, 15 (05) :411-418

[9] A SANDWICH ENZYME-LINKED-IMMUNOSORBENT-ASSAY FOR HUMAN INTERLEUKIN-5 [J].

FUKUDA, Y ;

HASHINO, J ;

HARUYAMA, M ;

TSURUOKA, N ;

NAKAZATO, H ;

NAKANISHI, T .

JOURNAL OF IMMUNOLOGICAL METHODS, 1991, 143 (01) :89-94

[10] FUNCTIONAL DOMAINS OF THE HUMAN GLUCOCORTICOID RECEPTOR [J].

GIGUERE, V ;

HOLLENBERG, SM ;

ROSENFELD, MG ;

EVANS, RM .

CELL, 1986, 46 (05) :645-652